Ionically Crosslinked Alginate/Carboxymethyl Chitin Beads for Oral Delivery of Protein Drugs

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Abstract
Summary: Complex beads composed of alginate and carboxymethyl chitin (CMCT) were prepared by dropping aqueous alginate‐CMCT into an iron(III) solution. The structure and morphology of the beads were characterized by IR spectroscopy and scanning electron microscopy (SEM). IR confirmed electrostatic interactions between iron(III) and the carboxyl groups of alginate as well as CMCT, and the binding model was suggested as a three‐dimensional structure. SEM revealed that CMCT had a porous morphology while alginate and their complex beads had a core‐layer structure. The swelling behavior, encapsulation efficiency, and release behavior of bovine serum albumin (BSA) from the beads at different pHs were investigated. The BSA encapsulation efficiency was fairly high (>90%). It was found that CMCT disintegrated at pH 1.2 and alginate eroded at pH 7.4 while the complex beads could effectively retain BSA in acid (>85%) and reduce the BSA release at pH 7.4. The results suggested that the iron(III)‐alginate‐CMCT bead could be a suitable polymeric carrier for site‐specific protein drug delivery in the intestine. Iron(III)‐alginate‐CMCT beads crosslinked in ferric chloride.