Synthesis of Novel Unsaturated Bicyclic Lactams by Ring-Closing Metathesis
- 1 October 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (10) , 1660-1662
- https://doi.org/10.1055/s-1999-2887
Abstract
An efficient and versatile synthetic method for the preparation of novel unsaturated fused bicyclic lactams is described. The crucial step of the stereoselective approach is the ring-closing metathesis reaction. The 6,5-, 7,5- and 8,5-fused 1-aza-2-oxobicycloalkenes can be obtained in five steps and good overall yield.Keywords
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