Ribosomal Heterogeneity from Chromatin Diminution in Ascaris lumbricoides
- 12 August 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 265 (5174) , 954-956
- https://doi.org/10.1126/science.8052853
Abstract
The genome of Ascaris lumbricoides encodes both germline- and soma-specific proteins homologous to the eukaryotic small ribosomal protein (Rp) S19. The two Ascaris homologs differ by 24 amino acid substitutions and are both components of the small ribosomal subunits. In oocytes, the germline RpS19 homolog (RpS19G) predominates. During chromatin diminution, however, the gene is eliminated from all presomatic cells, and RpS19G is replaced by the product of the somatic gene (RpS19S). Chromatin diminution in A. lumbricoides causes a change in the protein composition of ribosomes during development and represents an alternative means of gene regulation.Keywords
This publication has 25 references indexed in Scilit:
- Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genesPublished by Elsevier ,2004
- The occurrence, role and evolution of chromatin diminution in nematodesParasitology Today, 1993
- TRANS-SPLICING OF NEMATODE PREMESSENGER RNAAnnual Review of Microbiology, 1993
- Chromatin diminution in nematode developmentTrends in Genetics, 1992
- Isolation and nucleotide sequence of the ribosomal protein S16-encoding gene from Aspergillus nidulansGene, 1991
- New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in ascaris lumbricoidesCell, 1991
- The primary structure of rat ribosomal protein S19Biochimie, 1990
- Developmental Regulation of Two 5 S Ribosomal RNA GenesScience, 1988
- Primary structures of three highly acidic ribosomal proteins S6, S12 and S15 from the archaebacterium Halobacterium marismortuiFEBS Letters, 1987
- In the absence of ribosomal RNA synthesis, the ribosomal proteins of HeLa Cells are synthesized normally and degraded rapidlyJournal of Molecular Biology, 1977