Kindling Phenomenon: Impairment by Auditory Stimuli

Abstract
By coupling kindling stimuli with tones, it is shown that kindled epileptiform activity in the cat is not easily classically conditioned such that it can be evoked by an auditory stimulus. A tone presented 400 ms before and during the kindling stimulus impedes the rate of kindling. This phenomenon may have possible relevance as a model of long-term memory engram and epileptogenesis.