Molecular Characterization of Quinolone-Resistant Neisseria gonorrhoeae in Hong Kong
Open Access
- 1 January 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (1) , 436-439
- https://doi.org/10.1128/aac.47.1.436-439.2003
Abstract
In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87→Arg were associated with a higher level of resistance than a Ser-87→Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA , conferring Ala-92→Pro and Asp-95→Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes—11 to 19 repeats—were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.Keywords
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