Diuretic Therapy, Hypertension, and Cardiac Arrest

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Abstract
In this issue of the Journal, Siscovick et al. report a case-control study that evaluated the risk of cardiac arrest associated with diuretic treatment of hypertension1. The authors are aware of the pitfalls of a case-control study and have taken precautions to avoid them. An increasing dose of a thiazide diuretic was associated with an increasing rate of cardiac arrest. The combination of a thiazide diuretic and a potassium-sparing diuretic was associated with a lower rate of cardiac arrest than was found with a thiazide diuretic either alone or combined with potassium supplements. The rate of cardiac arrest was . . .