Antigen-Induced Cyclophosphamide-Resistant Suppressor T Cells Inhibit the in Vitro Generation of Cytotoxic Cells from One-Way Mixed Leukocyte Reactions

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Abstract
Mice sensitized against a tumor allograft and given cyclophosmamide 6 days later failed to generate an immune response to the allograft. Spleen cells derived from these mice suppressed the generation of cytotoxic T cell response by normal spleen cells in mixed leukocyte cultures. The suppressor cells were not specific, thymus dependent, and resistant to 2000 R.