COMPARATIVE ACTIVITY AND DISTRIBUTION STUDIES OF 5 PLATINUM ANALOGS IN NUDE-MICE BEARING HUMAN OVARIAN-CARCINOMA XENOGRAFTS

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (1) , 86-90
Abstract
The antitumor activity of 4 new Pt analogs was compared at equitoxic doses to that of cisplatin in B10 LP/cpb nude mice bearing xenografts of human ovarian carcinomas. The 2 tumor lines used, MRI-H-207 and Pe, differ in histology, tumor doubling time and sensitivity to cisplatin. Complete remission of MRI-H-207 was observed with cisplatin, carboplatin, iproplatin and JM-40, while spiroplatin only gave growth delay. Cisplatin and carboplatin caused some growth delay of Pe, while JM-40, spiroplatin and iproplatin failed to affect tumor growth. Pt tissue distribution was also measured for each compound in groups of 5-7 tumor-bearing mice. Pt concentrations in the 2 tumors at 24 h were similar for cisplatin and carboplatin, but differed for iproplatin, spiroplatin and JM-40. Organ distribution was similar for each analog and concentrations were significantly higher in kidneys than in liver, except for iproplatin with comparable concentrations in these organs. A good correlation was showed between analog-activity in ovarian cancer in the clinic and that in MRI-H-207. Pt concentrations in tumor tissue did not predict antitumor activity.