Study of neuronal gain in a conductance-based leaky integrate-and-fire neuron model with balanced excitatory and inhibitory synaptic input
- 1 August 2003
- journal article
- research article
- Published by Springer Nature in Biological Cybernetics
- Vol. 89 (2) , 119-125
- https://doi.org/10.1007/s00422-003-0408-8
Abstract
Neurons receive a continual stream of excitatory and inhibitory synaptic inputs. A conductance-based neuron model is used to investigate how the balanced component of this input modulates the amplitude of neuronal responses. The output spiking rate is well described by a formula involving three parameters: the mean μ and variance σ of the membrane potential and the effective membrane time constant τQ. This expression shows that, for sufficiently small τQ, the level of balanced excitatory-inhibitory input has a nonlinear modulatory effect on the neuronal gain.Keywords
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