Design and development of practical asymmetric syntheses of drug candidates

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Abstract
Recent progress in asymmetric syntheses has made a significant impact on strategies for drug development in the pharmaceutical industry. Under the recent guidelines by the Food and Drug Administration (FDA), many drug firms are no longer considering the development of racemic forms of chiral drugs. This lecture presents a few examples of highly practical stereoselective syntheses of drug candidates, shown below, discovered and developed at Merck Research Laboratories.

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