A FACILE ENTRY TO 3-(1-HYDROXYETHYL)-2-AZETIDINONES FROM METHYL (R)-3-HYDROXYBUTANOATE BASED ON THE ESTER ENOLATE-ALDIMINE CONDENSATION
- 5 November 1984
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 13 (11) , 1927-1930
- https://doi.org/10.1246/cl.1984.1927
Abstract
The reaction of the dianion of methyl (R)-3-hydroxybutanoate with the N-silylimine generated from trimethylsilylpropynal afforded (3R,4S)-3-[(R)-1-hydroxyethyl]-4-trimethylsilylethynyl-2-azetidinone as the major product, of which the stereochemistry was assigned through its stereospecific conversion to the (+)-4-acetoxy derivative.This publication has 11 references indexed in Scilit:
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