PRECOCIOUS SEXUAL DEVELOPMENT PRODUCED BY AN INTERSTITIAL CELL TUMOR OF THE TESTIS

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Abstract
A case of a functional interstitial cell tumor in a boy, 2.5 yrs. old,is reported including data on the 17-ketosteroid excretion. The blood studies were essentially normal except for a lowered serum Na of 248 mg. % and an elevated serum K of 27.6 mg.%. The ketosteroid excretion when the child was seen first, was 23 mg. per 24 hrs. An adrenal tumor was suspected but not verified at surgery. 5 months after the exploratory laparotomy and removal of the left adrenal gland, the ketosteroid excretion had increased to 64 mg. per 24 hrs. while the gonadotrophin excretion was within normal limits. The left testis was found enlarged and, on orchiectomy, an interstitial cell tumor within the center of the left testis was found. Thereafter, the 17-keto-steroid excretion fell progressively and amounted to 17 mg. per 24 hrs. 1 yr. after surgery. Simultaneously, there was a return to a more child-like body build, and the serum K returned to normal levels (17 mg.%).

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