Bile Volume and Excretion of Pigment and Bromsulfalein in Dogs Receiving Carbon Tetrachloride

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Abstract
Data were obtained on the rate of bile flow, biliary excretion of pigment and BSP and the response to Na cinchophen and Na dehydrocholate in unanesthetized tubulated duodenal-fistula dogs with varying degrees of liver functional impairment induced by prolonged admn. of CCl4. Decreased excretion of BSP was not accompanied by a consistent decrease in bile volume or endogenous pigment output until very low functional levels were reached. Progressive impairment of excretion of BSP and exogenous pigment was characterized most consistently by a progressively increasing delay in the peak of their concn. and excretion in the bile. Ability to concentrate dye, although generally impaired at decreasing functional levels, was frequently retained to a remarkable degree. Impairment of liver function did not affect significantly the choleretic response to Na cinchophen or Na dehydrocholate, except for a slight delay in the attainment of max. volume. Na cinchophen increased the output of endogenous pigment to a much greater extent than in animals with normal liver function. Apparently impairment of the capacity of the liver for excreting BSP and pigment is manifested first in delay in their transfer from the hepatic cells to the lumen of the bile canaliculi, their removal from the blood being initially relatively unaffected. With increasing functional damage, the hepatic cells become increasingly "saturated" with pigment and dye, with consequent increasing inability to.remove these substances effectively from the blood.

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