Role of Anions in Metabolic Alkalosis and Potassium Deficiency

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Abstract
STUDIES of acid–base physiology in recent years have defined many factors that influence the pH of the body fluids. A key step contributing to this progress has been the long delayed acceptance by renal physiologists of the modern physicochemical theory that considers acids as proton donors and bases as proton acceptors.1 , 2 It is now generally agreed that secretion of hydrogen ion by the renal tubule has a fundamental role in regulating body alkali stores and that the process of sodium-hydrogen exchange is the basic mechanism responsible for both acid excretion and bicarbonate reabsorption. A variety of studies suggest that the . . .
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