Immune Interferon Is a Growth Factor for Human Lung Fibroblasts1–4
- 1 November 1986
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 134 (5) , 1025-1028
- https://doi.org/10.1164/arrd.1986.134.5.1025
Abstract
A number of immunologically mediated lung disorders are characterized by the presence of fibrosis. In these studies, we demonstrate that immune (gamma) interferon, as well as interleukin-1 (IL-1), can function as a growth factor for human lung fibroblasts, Interleukin-2 has no effect on the proliferation of these cells. Interferon increases the proliferation of lung fibroblasts in a dose-dependent manner and functions as a progression factor by complementing the growthpromoting effects of a characterized competence factor such as fibroblast growth factor. These observations suggest that interferon, as well as IL-1, may play an important role in the fibrotic response as well as the immune response in the lung.Keywords
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