Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12
- 1 October 2002
- journal article
- research article
- Published by Elsevier in Neurobiology of Disease
- Vol. 11 (1) , 2-19
- https://doi.org/10.1006/nbdi.2002.0542
Abstract
No abstract availableKeywords
This publication has 75 references indexed in Scilit:
- Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNELNeurobiology of Aging, 2000
- Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical NeuronsJournal of Biological Chemistry, 2000
- DNA strand breaks in Alzheimer's diseaseBrain Research, 1999
- Caspase and calpain substrates: Roles in synaptic plasticity and cell deathJournal of Neuroscience Research, 1999
- Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in NeuronsJournal of Neuroscience, 1999
- Evidence for caspase‐mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's diseaseJournal of Neuroscience Research, 1999
- The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitroOncogene, 1999
- Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatumNeuroscience, 1998
- Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia NigraJournal of Neurochemistry, 1997
- Cell death induced by topoisomerase inhibitors: Role of calcium in mammalian cellsBiochemical Pharmacology, 1991