Cycloheximide Production by Streptomyces griseus : Control Mechanisms of Cycloheximide Biosynthesis
Open Access
- 1 June 1975
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 7 (6) , 856-860
- https://doi.org/10.1128/aac.7.6.856
Abstract
Cycloheximide accumulation in a fermentation medium has been shown to be the product of the balance between synthesis and degradation of this antibiotic. Glucose has been shown to prevent cycloheximide degradation. Cycloheximide has been shown to interfere with its own synthesis probably due to feedback inhibition. Approaches for increasing cycloheximide titers in the light of these findings are discussed.Keywords
This publication has 3 references indexed in Scilit:
- Cycloheximide Production by Streptomyces griseus : Alleviation of End-Product Inhibition by Dialysis-Extraction FermentationAntimicrobial Agents and Chemotherapy, 1975
- Metabolism of chloramphenicol by the producing organismCanadian Journal of Microbiology, 1970
- Metabolites ofStreptomyces nourseiFolia Microbiologica, 1969