Studies on the Complement Fixing Antigens of Poliomyelitis

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Abstract
Summary: The antibody responses of animals and man following infection and immunization with poliomyelitis viruses were investigated by absorption techniques. Sera from animals, immunized with a single type of virus, contained two distinct complement fixing antibodies, both of which were found to be type specific. The presence of antigenic components common to two or all three types of virus was demonstrated by absorption of a chimpanzee and a human serum with heated antigen preparations. Absorption of a human serum with native type II antigen gave direct evidence that this type of virus in its native state contains antigenic components present in the two heterologous types of virus whereas types I and III absorbed only their homologous antibodies.

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