Markers of Activated T Lymphocytes and T Cell Receptor Gamma/ Delta+ in Patients with Multiple Sclerosis
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 33 (2) , 152-155
- https://doi.org/10.1159/000116923
Abstract
We studied interferon-γ (IFN-γ), a-tumor necrosis factor (α-TNF) and granulocyte macrophage colony-stimulating factor (GM-CSF) in the cerebrospinal fluid and serum of 18 patients with multiple sclerosis (MS) and 10 subjects with other neurological diseases (OND). We also studied the cerebrospinal-fluid CD 69 expression, and T cells with T cell receptor (TcR) γ/δ+. We found an increase of IFN-γ (14.0 ± 3.5 U/ml) and GM-CSF (8.0 ± 3.4 pg/ml) levels in the cerebrospinal fluid of MS patients compared to the OND group (pKeywords
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