Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation

1 January 1996

journal article
research article
Published by Taylor & Francis in International Journal of Radiation Biology

Vol. 70 (2) , 145-150
https://doi.org/10.1080/095530096145139

Abstract

A group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07Gy per min) irradiation, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.

Keywords

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