A simultaneous transport‐reaction model for controlled drug delivery from catalyzed bioerodible polymer matrices
- 1 May 1985
- journal article
- research article
- Published by Wiley in AIChE Journal
- Vol. 31 (5) , 759-766
- https://doi.org/10.1002/aic.690310509
Abstract
A simultaneous diffusion‐reaction model is presented for the analysis of the kinetics of a chemically eroding poly(orthoester) matrix incorporated with a bioactive agent and with a catalyst to promote the erosion. Simulation results are consistent with experimentally observed hollow residuals and provide a basis for analyzing various design options.Keywords
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