The Synthesis of 3-Methyl-5-(2-aminoalkyl)isoxazoles
- 1 November 1973
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 46 (11) , 3533-3536
- https://doi.org/10.1246/bcsj.46.3533
Abstract
The reaction of 3,5-dimethylisoxazole with Scruff bases gave 3-methyl-5-(2-aminoalkyl)isoxazole derivatives in the presence of sodium amide in liquid ammonia. The N-alkylation on the anilino group of 3-methyl-5-(2-anilino-2-phenylethyl)isoxazole resulted in deamination, thus giving 3-methyl-5-styrylisoxazole. The reaction of 3,5-dimethylisoxazole with benzonitrile gave 3-methyl-5-(2-aminostyryl)isoxazole, which was then reduced to 3-methyl-5-(2-amino-2-phenylethyl)isoxazole.Keywords
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