Use of a New Adhesive Powder Vehicle (orahesive) for the Application of Drugs to Lesions of the Mouth

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Abstract
A previous report1 was concerned with the desirable properties of a new adhesive-vehicle-protectant preparation (Orabase)* designed especially for maintaining topically applied drugs on oral mucosal surfaces for longer periods than heretofore had been possible. It has been demonstrated that through the incorporation of medications in this vehicle drugs were retained on mucosal surfaces for an hour or more. Orabase, as a vehicle, offers the following advantages over previously used vehicles: (1) prolonged contact of active medication with oral tissues, (2) increased effectiveness of the active components by maintenance of higher concentrations at the desired site, and (3) the amount of active medication used could be decreased since it adhered more efficiently at the specific site. During the course of these investigations,2 it was noted that Orabase demonstrated a protectant action also, i.e., lesions of an erosive or ulcerative nature (traumatic ulcers, recurrent ulcerative stomatitis, erosive lichen planus, etc.),

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