β-Glucuronidase activity in lymphatic tissues of the rat after X-ray irradiation of the whole body

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Abstract
Weights and [beta]-glucuronidase activity were determined in lymphatic organs of rats (lymph nodes of the neck, thymus and spleen) 4 hours to 15 days after total-body irradiation (200, 400 and 600 r). The activity of the enzyme increased in the first period after the irradiation (from 4 hours to 5 days) when the tissues underwent a rapid decrease in weight. Histological examination showed extensive pycnoses of lymphocytes, fragmentation of cells and phagocytosis. In the 2d period, in which reconstitution of the tissues took place, the behavior of the enzyme was variable, depending on the organ and on the dose of radiation administered. After X-ray irradiation the positive correlation between increased [BETA]-glucuronidase activity and tissues atrophy, already found in fasting animals was confirmed. The increase in [BETA]-glucuronidase activity is a secondary radiation effect.

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