Preparation and antitumor activities of some derivatives of 5-methoxysterigmatocystin
- 1 November 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (11) , 1339-1342
- https://doi.org/10.1021/jm00233a018
Abstract
A series of derivatives of 5-methoxysterigmatocystin (3a,12c-dihydro-8-hydroxy-6,11-dimethoxy-7H-furo[3'',2'':4,5]furo[2,3-c]xanthen-7-one) was prepared and evaluated for anti-tumor activity in mouse P-388 leukemia. The potency of the parent compound was associated with the intact bisfurano ring system and the double bond in the terminal furan ring. New substituents can be introduced in the xanthone portion of the molecule and the anti-tumor activity is, in some cases, preserved.This publication has 0 references indexed in Scilit: