Uric Acid Nephropathy: An Experimental Model
- 1 February 1969
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 130 (2) , 512-516
- https://doi.org/10.3181/00379727-130-33593
Abstract
Summary A nephropathy was experimentally induced in rats by feeding a diet containing uric acid and oxonic acid, a uricase inhibitor. It was characterized by hyperuricemia, hyperuricosuria, deposition of uric acid in the kidney tubules, distention of tubular lumens, and early tubular and interstitial nephritis, and thus could serve as a useful experimental model for uric acid nephropathy.Keywords
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