Single Agent Chemotherapy for Head and Neck Cancers: The Murine Subrenal Capsule Assay
- 1 November 1983
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 109 (11) , 715-718
- https://doi.org/10.1001/archotol.1983.00800250009002
Abstract
• The murine subrenal capsule assay was used to determine chemotherapeutic sensitivities of metastatic, primary, or recurrent head and neck cancers. Tumor fragments (1 cu mm) were implanted under the renal capsule of 2- to 4-month-old normal female C57 BL/6 X DBA/2 F, hybrid mice. Xenografts included 20 squamous cell carcinomas (SCCs), one mucoepidermoid carcinoma, one adenoid cystic carcinoma, and two melanomas. Groups of tumor-bearing mice were treated with chemotherapy daily for five days. Sensitivities of the tumor were assessed on day 6 by comparison of final implant size with initial implant size. Significant oncolytic activity was detected against 16 of 24 tumors (14 of 20 SCCs and both melanomas). Correlations between the in vivo assay and clinical studies are needed to determine its predictive value. (Arch Otolaryngol 1983;109:715-718)Keywords
This publication has 2 references indexed in Scilit:
- Chemotherapy in Head and Neck CancerNew England Journal of Medicine, 1983
- The clonal assay of head and neck tumor cells: Results and clinical correlationsThe Laryngoscope, 1982