Breath-to-breath monitoring of inspiratory occlusion pressures in humans

Abstract
A pneumatically driven occlusion device was designed to implement brief (.apprx. 130 ms) inspiratory airway occlusion and to monitor the associated inspiratory occlusion pressure (P100) on a breath-to-breath basis in humans. The device, which had a low resistance when patent, provides no discernible modulation of ventilation during steady and nonsteady states of moderate intensity cycle-ergometer exercise. With this technique, it is possible to investigate dynamic and steady-state P100 responses to stimuli such as exercise, inhaled CO2 and hypoxia.

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