α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Top Cited Papers
- 24 September 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 329 (5999) , 1663-1667
- https://doi.org/10.1126/science.1195227
Abstract
α-Synuclein and Aging: Transgenic α-synuclein can reverse the otherwise lethal neurodegeneration of cysteine string protein-α knockout mice via changes in SNARE proteins, which mediate synaptic vesicle release. Using experiments with purified recombinant proteins, triple αβγ-synuclein knockout mice, and studies of mouse aging, Burré et al. (p. 1663 , published online 26 August) now demonstrate that α-synuclein directly interacts with the SNARE protein synaptobrevin and functions as a catalyst for SNARE-complex assembly. The role of synucleins is fully dispensable in young animals, but becomes essential late in life, which suggests that α-synuclein maintains normal synaptic function during aging.Keywords
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