Primary Tumor Levels of Tissue Inhibitor of Metalloproteinases-1 Are Predictive of Resistance to Chemotherapy in Patients with Metastatic Breast Cancer
- 1 December 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (23) , 7054-7058
- https://doi.org/10.1158/1078-0432.ccr-06-0950
Abstract
Purpose: Only about 50% of metastatic breast cancer patients benefit from cytotoxic chemotherapy. Today, no validated markers exist for prediction of chemotherapy sensitivity/resistance in this patient group. Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been shown to protect against apoptosis, and the purpose of the present study was to test the hypothesis that tumors expressing high levels of TIMP-1 are protected against apoptosis-inducing agents and thus less sensitive to apoptosis-inducing chemotherapeutic drugs.Keywords
This publication has 24 references indexed in Scilit:
- Measurement of the Uncomplexed Fraction of Tissue Inhibitor of Metalloproteinases-1 in the Prognostic Evaluation of Primary Breast Cancer Patients*Molecular & Cellular Proteomics, 2005
- Urokinase-Type Plasminogen Activator System in Breast CancerCancer Research, 2004
- Tumor Tissue Levels of Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Marker in Primary Breast CancerClinical Cancer Research, 2004
- Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP‐3 is associated with adjuvant endocrine therapy successThe Journal of Pathology, 2004
- Tissue Inhibitor of Metalloproteinase-1 Protects Human Breast Epithelial Cells Against Intrinsic Apoptotic Cell Death via the Focal Adhesion Kinase/Phosphatidylinositol 3-Kinase and MAPK Signaling PathwayJournal of Biological Chemistry, 2003
- Tumor Tissue Concentrations of the Proteinase Inhibitors Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and Plasminogen Activator Inhibitor Type 1 (PAI-1) Are Complementary in Determining Prognosis in Primary Breast CancerMolecular & Cellular Proteomics, 2003
- Complex roles of tissue inhibitors of metalloproteinases in cancerOncogene, 2002
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002
- Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serumFEBS Letters, 1992
- Molecular characterization and expression of the gene encoding human erythroid-potentiating activityNature, 1985