Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration.

  • 1 July 1977
    • journal article
    • Vol. 61  (4) , 745-8
Abstract
A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

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