Involvement of Insula and Cingulate Cortices in Control and Suppression of Natural Urges
Open Access
- 9 May 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in Cerebral Cortex
- Vol. 19 (1) , 218-223
- https://doi.org/10.1093/cercor/bhn074
Abstract
The physiology of control and suppression of natural urges is not well understood. We used [15O]H2O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.Keywords
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