Improvement of High-Density Lipoprotein-Cholesterol Levels

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Abstract
Twelve ambulatory patients (six women and six men; mean age, 29 years) with type I diabetes were treated with a continuous subcutaneous open-loop insulin pump in an attempt to effect better glucose control. Hemoglobin A1, mean blood glucose, total cholesterol, total triglycerides, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and the cholesterol/HDL-C ratio were assessed monthly before and after glucoregulation from five to 14 months (mean, nine months). Mean HDL-C levels increased significantly (52±4 to 60±5 mg/dL); mean cholesterol/HDL-C ratios decreased significantly (4.46±0.43 to 3.89±0.39). Mean values for triglycerides, total cholesterol, and LDL-C, all initially normal, did not change. Both mean Hb A1levels and glucose levels fell from 11.2%±0.5% to 9.8%±0.5% and 177±15 mg/dL to 128±12 mg/dL, respectively. Insulin requirements decreased from 0.80±0.08 to 0.61±0.05 units/ kg/24 hr. These results may favorably alter the prediction for development of accelerated atherosclerosis in type I diabetics. (JAMA1982;247:37-39)