Toxins-Antitoxins: Plasmid Maintenance, Programmed Cell Death, and Cell Cycle Arrest
Top Cited Papers
- 12 September 2003
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 301 (5639) , 1496-1499
- https://doi.org/10.1126/science.1088157
Abstract
Antibiotic resistance, virulence, and other plasmids in bacteria use toxin-antitoxin gene pairs to ensure their persistence during host replication. The toxin-antitoxin system eliminates plasmid-free cells that emerge as a result of segregation or replication defects and contributes to intra- and interspecies plasmid dissemination. Chromosomal homologs of toxin-antitoxin genes are widely distributed in pathogenic and other bacteria and induce reversible cell cycle arrest or programmed cell death in response to starvation or other adverse conditions. The dissection of the interaction of the toxins with intracellular targets and the elucidation of the tertiary structures of toxin-antitoxin complexes have provided exciting insights into toxin-antitoxin behavior.Keywords
This publication has 38 references indexed in Scilit:
- The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteriaNature, 2003
- Enterococcus faecalisPlasmid pAD1-Encoded Fst Toxin Affects Membrane Permeability and Alters Cellular Responses to LantibioticsJournal of Bacteriology, 2003
- The Bacterial Toxin RelE Displays Codon-Specific Cleavage of mRNAs in the Ribosomal A SitePublished by Elsevier ,2003
- Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35‐amino‐acid cell‐killing peptide and a cis‐encoded small antisense RNA in Escherichia coliMolecular Microbiology, 2002
- The Highly Conserved TldD and TldE Proteins of Escherichia coli Are Involved in Microcin B17 Processing and in CcdA DegradationJournal of Bacteriology, 2002
- On the origin, evolution, and nature of programmed cell death: a timeline of four billion yearsCell Death & Differentiation, 2002
- Bacterial death induced by expression of the intracellular portion of human FasCell Death & Differentiation, 1999
- Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to thepassystem of pTF-FC2FEMS Microbiology Letters, 1999
- THINKING ABOUT BACTERIAL POPULATIONS AS MULTICELLULAR ORGANISMSAnnual Review of Microbiology, 1998
- The entericidin locus of Escherichia coli and its implications for programmed bacterial cell deathJournal of Molecular Biology, 1998