Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.

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Abstract
In mice, 2 families of structurally distinct Ia molecules, one designated I-A and the other I-E, have been identified and characterized. The HLA-DR molecules represent 1 family of human Ia molecules equivalent to the murine I-E molecules on the basis of amino acid sequence homology. The isolation and biochemical characterization of a 2nd family of human Ia molecules, designated HLA-DS for 2nd D-region locus, equivalent to the murine I-A molecules is described. The human HLA-DS molecules consist of 2 polypeptide chains, DS.alpha. (37,000 MW) and DS.beta. (29,000 MW), with 73% amino acid sequence identity to the murine I-A molecules. The HLA-DS molecules are closely linked genetically to HLA-DR molecules, a situation analogous to that observed in mice. The similarity in MW of the DR and DS molecules might explain why others have failed to identify the latter in man.

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