Psychedelic-Induced Social Behavior in Mice: A Preliminary Report

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Abstract
When large populations of mice were treated with LSD (2mcg/kg to 30mcg/kg), bufotenine (5mg/kg to 30mg/kg), a cannabis sativa extract (50mg/kg to 100mg/kg), or tetrahydrocannabinol (2mg/kg to 10mg/kg), there was a dramatic change in social behavior. Such treatment produced a significant reduction in aggression, group aggregation, and temporary disruptions of social hierarchies. Hallucinogenic-treated mice placed in normal untreated colonies were hypersensitive to auditory and tactile stimulation and aggregated in small groups apart from the rest of the population. Treatment with saline or BOL-148 produced no significant changes in behavior.