Treatment of HCV-Related Mantle-Cell Lymphoma with Ribavirin and Pegylated Interferon Alfa

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Abstract
We expand on the data presented by Hermine et al., who demonstrated the antitumor efficacy of interferon alfa in hepatitis C virus (HCV)–infected patients with marginal-zone lymphoma.1 We report the details of anti-HCV therapy in the patient from whom we established a B lymphoma cell line that is persistently infected with HCV.2 In culture, the line continuously produces HCV, which can infect primary human hepatocytes, peripheral-blood mononuclear cells, and Raji cells.