Two Dimensional1H NMR Study of d(br5C-G)3in the Z-Form. Self Association and Flexibility of the Left Handed Double Helix
- 1 August 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Biomolecular Structure and Dynamics
- Vol. 5 (1) , 67-78
- https://doi.org/10.1080/07391102.1987.10506375
Abstract
The Z conformation of the auto complementary hexanucleoside pentaphosphate d(br5C-G)3 in 1 M NaClO4 solution has been investigated by using 2D NMR techniques. NOESY experiments performed at different temperatures show that the oligonucleotide exhibits end- to-end associations at room temperature. The conformation of the hexanucleotide molecules is very similar to that found in the crystal which was described by Chevrier et al. (J. Mol. Biol., 1986, 188, 707–719) as a Z-I form. When the temperature is increased the aggregates are dissociated and a conformational change is observed which is interpreted as a Z-I ⇋ Z-II transition.This publication has 17 references indexed in Scilit:
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