Correlation Between Sodium-, Potassium-Stimulated ATPase Activity and Renal Function After Transplantation of Canine Kidneys

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Abstract
The Na+-, K+-stimulated ATPase activity in kidney tissue slices from 32 dogs was studied after hypothermic preservation for 12–96 h (n =15) or continuous hypothermic perfusion of the kidey for 48–168 h (n = 17). The ATPase activity Kidney transplants was related to the renal function after autotransplantation and contralateral nephrectomy. In 25 out of 32 dogs (80%) a positive correlation was found, i.e. there was a preserved ATPase activity and a good renal function or absence of ATPase activity and no renal function after auto transplantation. An ATPase activity was found in 6 dogs but the kidneys did not function. In 3 of the dogs a urine like fluid was continuously produced, but the kidneys did not have the capacity to decrease the serum creatinine within 3 weeks. In 2 of the 6 kidneys, the vessels were occluded by thrombi. In only one kidney was no ATPase activity recovered, although the kidney functioned well after transplantation. This single observation might be explained by a nonrepresentative biopsy or by technical failure in determining the ATPase activity. Conclusion: the reliability of determining the Na+-, K+-ATPase activity as a viability test for kidney transplants is fairly good.

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