Passive Immunity in Helicobacter -Challenged Neonatal Mice Conferred by Immunized Dams Lasts until Weaning
Open Access
- 1 April 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (4) , 2226-2229
- https://doi.org/10.1128/iai.71.4.2226-2229.2003
Abstract
The objective of this study was to examine the effect of breast-feeding by immunized dams on Helicobacter colonization in newborns. Urease-based immunization regimens failed to protect nursing pups against H. felis , whereas H. felis lysate-cholera toxin resulted in protection. This observation correlated with a high recognition of cell surface-expressed bacterial antigens by milk antibodies. Protection lasted until weaning, indicating that infection is maintained at undetectable levels by passive immunity but then resumes when breast-feeding stops.Keywords
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