Blood Granulocyte-Macrophage Progenitor Cell Concentrations and Differentiation in vitro in Patients with Hepatic Cirrhosis

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Abstract
Blood granulocyte-macrophage progenitor cells (CFU-GM) and myeloid differentiation were studied in 16 patients with hepatic cirrhosis by culturing blood mononuclear cells in semisolid and in liquid medium. The numbers of CFU-GM from normal and cirrhotic subjects were not significantly different, even when increased numbers of monocyte-macrophagic colonies and decreased numbers of granulocytic colonies were observed in cirrhotic patients. Significantly reduced granulocytic growth and increased monocyte-macrophagic cell growth were found in liquid culture of cirrhotic patients. In hepatic cirrhosis, besides granulocyte sequestration within the spleen, there apparently is a disorder of granulocytic vs. monocyte-macrophagic differentiation.