Tumor Suppression in Xiphophorus by an Accidentally Acquired Promoter
- 5 February 1993
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 259 (5096) , 816-819
- https://doi.org/10.1126/science.8430335
Abstract
Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.Keywords
This publication has 12 references indexed in Scilit:
- Transient expression directed by homologus and heterologous prometer and enhancer sequences in fish cellsNucleic Acids Research, 1990
- An automated method for calcium phosphate-mediated gene transferTrends in Genetics, 1989
- Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in XiphophorusNature, 1989
- Characterization of the promoter region of the human c-erbB-2 protooncogene.Proceedings of the National Academy of Sciences, 1987
- CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elementsNucleic Acids Research, 1987
- Promoters for housekeeping genesTrends in Genetics, 1986
- A comprehensive set of sequence analysis programs for the VAXNucleic Acids Research, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- A Genetic Concept of the Origin of Cancer, Based in Part upon Studies of Neoplasms in Fishes1Published by S. Karger AG ,1975
- Über Kreuzungen zwischen den Teleostiern Xiphophorus Helleri und Platypoecilus maculatusMolecular Genetics and Genomics, 1928