Effect of Substituted Benzimidazoles on H+K+ATPase of Isolated Guinea-pig Parietal Cells
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 21 (sup118) , 52-53
- https://doi.org/10.3109/00365528609090889
Abstract
Omeprazole, a substituted benzimidazole, has been shown to inhibit gastric acid secretion in vitro and in vivo. In vitro, omeprazole inhibits acid secretion stimulated at all cellular levels, including that stimulated by K+, indicating that it is an inhibitor of the parietal cell proton pump. The present paper describes the inhibitory effect of substituted benzimidazoles, such as picoprazole and omeprazole, on the H+K+ATPase isolated from guinea-pig parietal cells, and the reversibility of acid inhibition in isolated guinea-pig parietal cells by the thiol compound, dithiothreitol.Keywords
This publication has 3 references indexed in Scilit:
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- Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells.Gut, 1983
- Effects of Secretagogues on Oxygen Consumption, Aminopyrine Accumulation and Morphology in Isolated Gastric GlandsActa Physiologica Scandinavica, 1976