The kinase activity of DNA-PK is required to protect mammalian telomeres

• 4 March 2004
• journal article
• research article
• Published by Elsevier in DNA Repair
• Vol. 3  (3) , 225-233
• https://doi.org/10.1016/j.dnarep.2003.10.013

Abstract

Keywords

• DSB
• DOUBLE-STRAND BREAK
• DNA-PK
• DNA-DEPENDENT PROTEIN KINASE
• DNA-PKCS
• DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
• TRF2
• TELOMERE REPEAT BINDING FACTOR 2
• FISH
• FLUORESCENCE IN SITU HYBRIDIZATION
• CO-FISH
• CHROMOSOME-ORIENTATION FLUORESCENCE IN SITU HYBRIDIZATION
• SCID
• SEVERE COMBINED IMMUNO-DEFICIENCY
• NHEJ
• NON-HOMOLOGOUS END JOINING
• HOMOLOGOUS RECOMBINATION
• BRDU
• 5′-BROMO-2′-DEOXYCYTIDINE
• BRDC