EFFECTS OF INTRAVENOUS INFUSIONS OFdl-ALDOSTERONE ACETATE ON SODIUM AND POTASSIUM EXCRETION IN MAN*

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Abstract
Intravenous infusions of dl-aldosterone monoacetate in 5 per cent glucose-water were given at a rate of 4.2 [mu]g per minute over an eight-hour period to 3 patients with Addison''s disease who received two-hourly feedings during the 24-hour period of study. Urine collections were made at two-hourly intervals. Following the commencement of the infusions two hours elapsed before an appreciable effect on sodium and potassium excretion was observed. Sodium antidiuresis and potassium diuresis then occurred and lasted four to six hours after stopping the infusion. No consistent effect on salivary Na/K ratio or on circulating eosinophils was noted. The simultaneous infusion of 20 mg. of hydro-cortisone over the eight-hour period did not modify the effect of aldosterone on sodium excretion but caused an increase in potassium diuresis. Serum sodium and potassium concentrations both fell during the period of study.