ONE-WAY OCCURRENCE OF GRAFT-VERSUS-HOST DISEASE IN BONE-MARROW CHIMERAS BETWEEN CONGENIC MRL MICE

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 53  (2) , 251-256
Abstract
Bone marrow cells (BMC) of MRL Mp-lpr/lpr (MRL/l) mice, when infused into irradiated MRL Mp-+/+ (MRL/n) mice, induced graft-vs.-host disease (GVHD) and recipients died of wasting syndromes beginning approximately a few weeks later. Protracted appearance of GVHD was observed when (MRL/n .times. MRL/l)F1 mice were used as recipients of MRL/l BMC. MRL/n BMC did not elicit GVHD in irradiated MRL/l mice. Treatment of MRL/l BMC with anti-Thy-1 antiserum plus complement did not eliminate GVHD-provoking capacity. Thymectomy of the recipients reduced the incidence of GVHD. No apparent reaction was observed in mutual mixed lymphocyte culture of spleen cells from MRL/l and MRL/n mice. Injected T cell precursors of MRL/l mice apparently become mature through the host (MRL/l mice) thymus and appear in the periphery as functioning T cells, resulting in the appearance of GVHD.

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