Lack of Correlation Between Skin Test and "Tissue" Sensitivities in Guinea Pigs Infected with Brucella abortus.

Abstract
Guinea pigs experimentally infected with large doses of B. abortus and from which the organisms could be recovered at the time of sacrifice did not always show a positive skin test to brucella extract. In vitro testing of splenic tissue, however, showed the large wandering cells to be sensitive to the extract in most cases. The authors conclude that the in vitro test is a better indication of allergy than is the skin test.

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