USE OF CU-DTPA-TC-99M COMPLEX AS A RENAL-FUNCTION AGENT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (1) , 62-66
Abstract
The use of cuprous ion as a reducing agent for pertechnetate was described for the 1st time. The potential usefulness of a 99mTc-Cu-DTPA [diethylenetriaminepentacetate] complex as a renal function agent was evaluated by organ distribution studies in animals and by simultaneous continuous-infusion and single-injection clearance studies. Radioiodinated iothalamate was used as a standard for the measurement of GFR [glomerular filtration rate]. The ratio for the clearance with the new Cu complex to that with iothalamate was close to unity, both for continuous infusion (0.97 .+-. 0.01 SE) and for single injection (1.05 .+-. 0.03). The coefficients of correlation were similarly close to unity: 0.96 and 0.99, respectively. Dialysis of plasma samples obtained after injection of 99mTc-Cu-DTPA into bilaterally nephrectomized rats indicated that only small amounts (< 4%) of the complex are protein-bound. These data and the low toxicity of the Cu preparation in animals appeared to justify its investigation for kidney function measurement and imaging in man as well as its use as a GFR agent in animal studies.

This publication has 1 reference indexed in Scilit: