The Proliferation Behavior of Bone Tumors Investigated with the Monoclonal Antibody Ki-67

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Abstract
Bone tumors are a rare kind of neoplasm. Their varied clinical manifestations, together with their rarity of occurrence, involve the pathologist in considerable difficulties in differentiating benign or merely reactive changes from malignant disease. Correct diagnosis of bone tumors calls for close interdisciplinary Cooperation, but even then the difficulties may be grave, and sometimes hardly surmountable in differential diagnosis. Further improvement in the prognosis of malignant osseous neoplasm — beyond the progress seen in recent years — will be achieved only by earlier recognition and greater diagnostic accuracy. Any diagnostic considerations should therefore be centered upon the recognition of the tumor type and its biological behavior.