Ultrastructural Abnormalities In Whipple's Disease.

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Abstract
A fasting jejunal biopsy specimen, obtained from a patient with Whipple''s disease, was studied by light and electron microscopic technics. Periodic acid-Schiff positive inclusions in the macrophages were found to have a complex ultrastructure consisting of a series of membranes, vesicles and granules. Dense bodies of unknown nature were observed in close approximation to the macrophage cell border, and within its substance. The virus-like character of these particles has been discussed.